Mechanisms of Neutropenia Involving Myeloid Maturation Arrest in Burn Sepsis
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چکیده
منابع مشابه
MYELOID NEOPLASIA Immunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia
The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide yield high response rates in patients with multiple myeloma, but the use of IMiDs in multiple myeloma is associated with neutropenia and increased risk for venous thromboembolism (VTE) by mechanisms that are unknown. We show that IMiDs downregulate PU.1, a key transcription factor involved in granulocyte differentiation in vitro a...
متن کاملImmunomodulatory derivatives induce PU.1 down-regulation, myeloid maturation arrest, and neutropenia.
The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide yield high response rates in patients with multiple myeloma, but the use of IMiDs in multiple myeloma is associated with neutropenia and increased risk for venous thromboembolism (VTE) by mechanisms that are unknown. We show that IMiDs down-regulate PU.1, a key transcription factor involved in granulocyte differentiation in vitro ...
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Fig. 1. Bone marrow aspirate (A, May-Grunwald Giemsa stain, ×400) and biopsy (B, Haematoxylin-eosin stain, ×400) of patient 1 showing myeloid maturation arrest. 5. Farah C, Bulai Livideanu C, Jegu J, et al. Prevalence and prognostic value of cutaneous manifestations in patients with myelodysplastic syndrome. J Eur Acad Dermatol Venereol 2010;24: 1171-5. 6. Avivi I, Rosenbaum H, Levy Y, Rowe J. ...
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For human IVF, the patient's ovaries are hormonally stimulated to ensure the collection of fully matured oocytes that are at the metaphase II stage. Only these oocytes can be successfully fertilized either when mixed with sperm or after ICSI. Nevertheless, in some cases immature or maturing oocytes are recovered from follicles. Surprisingly, sometimes these oocytes do not complete maturation wh...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1998
ISSN: 0003-4932
DOI: 10.1097/00000658-199807000-00017